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KMID : 0545120020120050858
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Journal of Microbiology and Biotechnology
2002 Volume.12 No. 5 p.858 ~ p.863
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Antibacterial and Antifungal Activities of a Naphthoquinone Derivative Isolated from the Fruits of Catalpa ovata G. Don
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KUK, JU-HEE
MA, SEUNG-JIN/MOON, JAE-HAK/KIM, KIL-YONG/CHOI, SANG-HO/PARK, KEUN-HYUNG
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Abstract
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An antimicrobial compound was isolated from the MeOH extract of Catalpa ovata G. D_ON fruits, and its structure was identified as 4, 9-dihydroxy-2, 2-dimethyl-3, 4-dihydronaphtho[2, 3-b]pyran-5, 10-dione (HMNP). The antimicrobial activity of the HMNP was determined by measuring the dose-response inhibition of microbial growth in liquid cultures and then compared with that of lapachol, a well known antimicrobial 1, 4-naphthoquinone. The antimicrobial activity of the HMNP was more effective than that of lapachol over a wide range of test organisms. Gram-positive bacteria, yeast, and fungi (IC_50 20-75㎛) were found to be more sensitive to the HMNP than Gram-negative bacteria (IC_50>100㎛). The HMNP also inhibited germination of spores of many fungi. The morphological deformation of the fungal spores was induced by the treatment of HMNP, as illustrated by Scanning Electron Microscopy (SEM).
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